Lachesis was the first snake to be included in the homeopathic materia medica. To this day, it remains the best known with the most number of symptoms. Mure’s ‘proving’ of Crotalus cascavella in the early 1840s involved only a single person in addition to the treatment of a woman suffering from a type of manic psychosis in relation to an off-schedule [intermenstrual?] uterine bleeding – “She feels uncomfortable in consequence of having her courses, and is out of humour on account of having them.” In this connection it should be noted that Mure was well aware of the use of Lachesis. He expected that his Crotalus would work even better than Lachesis, presumably in such cases as this one, given his remark that, “The Crotalus will become a useful adjunct to the Lachesis proved by Doctor Hering; it is my belief that it affects the organism longer and more thoroughly than the latter, and will effect many cures that had to remain incomplete under the use of Lachesis.” The treatment was not successful, yet despite this many of our current Crot-c. symptoms are derived from this case.
We now have over 100 snake remedies and more distinctive divisions have been described. Snake remedies can be divided by toxicology, zoology, habitat and behavior. Lachesis is a haemotoxic snake and Crotalus cascavella is a neurotoxic one. This is one reason Mure’s case of bleeding was not affected by Crot-c.
NEUROTOXIC In contrast to the haemotoxicity of most pit vipers, cascavel venom is predominantly neurotoxic, with some haemotoxic and myotoxic factors, and the bite pathology is representative of this. Bites are almost devoid of localised symptoms and instead follow the pattern more expected from the bite of the neurotoxic elapids with potential blindness, paralysis and inhibition of respiration. Bite symptoms are very different from those of Nearctic haemotoxic species due to the presence of neurotoxins such as crotoxin and crotamine that cause progressive paralysis. Bites from Crotalus durissus terrificus in particular can result in impaired vision or complete blindness, auditory disorders, ptosis, paralysis of peripheral muscles, esp. of the neck, which becomes so limp as to appear broken, and eventually life-threatening respiratory paralysis.
PAIN & PARESIS “Pain, often stinging in character, is a consistent complaint following the bite of this snake. The pain may be followed by a feeling of numbness over the affected part. Oedema rarely develops, and ecchymosis, if it occurs, is limited to the area of the bite. Bleb formation does not occur. Visual disturbances develop within 1 hour of the bite, and ophthalmoplegia and blepharoplegia develop soon after, in some cases. Pupillary reflexes are usually intact. Rosenfeld noted the presence of ‘the neurotoxic facies’ [uni- or bilateral ptosis and paralysis of facial muscles], which is diagnostic of Crotalus durissus terrificus bites. Muscle pain and weakness may develop.
“Paresis may be most notable in the muscles of the back of the neck. In the 2 cases seen by the author, fine muscle fasciculations were observed in the neck and face, although they were most notable over the tongue. In severe poisoning, there may be vomiting, decreased deep reflexes, prostration, and coma. Methaemoglobinuria may occur within 6 hours of the bite and is often followed by anuria in the more severe envenomations. Pulse and blood pressure may be normal until late in the course of the poisoning.” [Russell]
Quoted from Prisma Reference by Frans Vermeulen